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KMID : 0603520020070010042
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Journal of Korean Association of Cancer Prevention
2002 Volume.7 No. 1 p.42 ~ p.50
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Effects of Dahuang and Soamsan on Angiogenic Mechanism
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Shin Hyun-Ah
Nam Myung-Jin
Kim Jae-Hyoun
Om Ae-Son
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Abstract
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Angiogenesis is a complex process involving a cascade of events that result in the formation of new blood vessels from existing ones. This process are known to be essential for tumor growth, survival and metastasis. There are a number of angiogenic factors controlling the process. The present study was conducted to assess the effects of 0.l mg/ml dahuang and 1.0 mg/ml soamsans on human hepato-carcinoma (SNU449) and gastric-adenocarcinoma (SNU638) induced tube formation, proliferation and migration of vascular endothe1ial cells (ECV304), and on expressions of angiogenic factors (VEGF, TGF-β and PDGF) in vitro. In SNU449 cells, the expressions of VEGF, TGF-β and PDGF were inhibited by dahuang. In SNU638 cells, the expression of VEGF was inhibited by dahuang and soamsan, but TGF-β was inhibited only by soamsan. In ECV304 cells, tube formation and migration were inhibited by dahuang and soamsan. The cell proliferation induced by SNU449 CM seemed to be significantly inhibited by dahuang (78%, p<0.05) and soamsan (67%, p<0.01). However, the cell proliferation induced by SNU638 CM was significantly inhibited only by dahung (56%, p<0.Ol). According to the results, dahuang and soamsan seemed to inhibit angiogenesis mechanism, therefore they are thought to be a potential anti-cancer materials.
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KEYWORD
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Angiogenesis, Hepato-carcinoma, Gastric-adenocarcinoma, Dahuang, Soamsan
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